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discovery programsOur Testing Catalogue

 

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procradAssay Development

 

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lockradTarget
Discovery

 

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Profiling

 

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HTS
 

 

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Profiling

We provide a complete cell or membrane-based profiling service to evaluate potential side-effects of your lead compound or identify the therapeutic target for a biologically active molecule. We are offering ready-to-use profiling package but you can pick the targets from our catalogue to set-up your personalized profiling.

SELECTIVITY FUNCTIONAL PROFILING

We offer a 57 human GPCRs profile covering main families with known or anticipated side-effects or liabilities. Our package includes:

-           Natural coupling readout

-          Your compound tested in 1 conc, duplicates

-          Agonist and Antagonist mode of action

-          Turnaround time: 3 weeks

ESFAST Website SELECTIVITY FUNCT PROF

 

SAFETY PROFILING

 

We offer a 44 targets profile containing GPCR, ion channels and enzymes for efficient off-target effect screening. Our package includes:

-   Binding assay for receptor targets

-   Biochemical assay for enzyme targets

-   Your compound tested in 1conc, duplicates

-   Turnaround time: 3 weeks

 

           ESFAST Website Safety profiling

  

 

GPCR FAMILY FUNCTIONAL PROFILING

We provide specific receptor family panels such as human and mouse chemokine, human serotonin, human and rat muscarinic, human mGlu receptors. 

              CHEMOKINE RECEPTORS PROFILING

-        Your compound tested in 1 conc, duplicates

-         Agonist and Antagonist mode of action

-        Turnaround time: 3 weeks

                   ESFAST Website CHEMOKINE RECEPTOR

             METABOTROPIC GLUTAMATE RECEPTORS PROFILING

-          Your compound tested in 1 conc, duplicates

-          Agonist , Antagonist/NAM and PAM mode of action

-          Turnaround time: 2 weeks

       ESFAST Website METABOTROPIC Glutamate

             SEROTONIN RECEPTORS PROFILING

-          56 targets

-          Your compound tested in 1 conc, duplicates

 -          Agonist and  Antagonist mode of action

-      Turnaround time: 2 weeks

Serotonin profile2

THERAPEUTIC FUNCTIONAL PROFILE

We provide therapeutic area profiles such as inflammatory, sensory/pain, metabolic, CNS diseases.

We provide therapeutic area profile such as inflammatory, sensory/pain, metabolic, CNS diseases.

            INFLAMMATION PANEL

-          56 targets

 -          Your compound tested in 1 conc, duplicates

 -          Agonist and  Antagonist mode of action

 -          Turnaround time: 3 weeks

ESFAST Website inflamation profile

             SENSORY / PAIN PANEL

 -          42 targets

-          Your compound tested in 1 conc, duplicates

-          Agonist and  Antagonist mode of action

-         Turnaround time: 3 weeks

ESFAST Website SENSORY PAIN Panel

             CNS PANEL

-          37 targets

-          Your compound tested in 1 conc, duplicates

-          Agonist and  Antagonist mode of action

-         Turnaround time: 3 weeks

CNS panel

            METABOLIC PANEL

-          54 targets

-          Your compound tested in 1 conc, duplicates

-          Agonist and  Antagonist mode of action

-          Turnaround time: 3 weeks

ESFAST Website METABOLIC PANEL

EFFICACY / ADMET PROFILE

In order to speed up your drug candidate selection and save cost we offer a GPCR efficacy/ADMET profiling data package in 7 working days including:

                           ESFAST Website EFFICACY ADMET PROF


 


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